This presentation will examine how CHHS advanced vaccine uptake by pairing a multi layered vaccine confidence strategy with a deep commitment to health equity. Using the Rise to Immunize® framework, CHHS embedded confidence building techniques across provider education, clinical support, IT workflows, patient communication, and community engagement. These efforts included culturally responsive training, standardized messaging, trusted messenger outreach, transparent patient facing information, and consistent EMR driven prompts. At the same time, equity focused data analysis revealed disparities by language, age, gender, and social vulnerability, guiding targeted interventions for New Americans and residents of high ADI neighborhoods. Through this dual approach - strengthening confidence while removing structural and cultural barriers - CHHS delivered more than 69,000 vaccines over 3 years and achieved year over year improvements in respiratory vaccine uptake. The session will demonstrate how coordinated, equity centered, system wide action can meaningfully expand preventive care access and build lasting vaccine confidence across diverse communities.